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KMID : 0361519930040010033
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Korean Journal of Psychopharmacology
1993 Volume.4 No. 1 p.33 ~ p.38
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Central Nervous System Receptor Binding Study for the Composing Drugs of Whangryeonhaedoktang
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Abstract
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In an effort to investigate the biological mechanism of Whangryeonhaedoktang which was reported to be effective for mental disotders, we conducted a radio-liggnad receptor binding assay for dopamine-2 and serotonin-2 receptors with Whangkeum.
Whangryeon, Sanchija and Whangbaek of which Whangryeonhaedoktang is composed.
@ES The results were as follows.
@EN 1) For D2 receptor analysis with 3 [H] spiperone as radio-ligand. The striatal tissues of male Spraue-Dawley rats were used. The Bmax of the receptor was 146.54 fmole/mg protein and the Kd was 0.38 nM as the basic data of studies. None of
them
showed affinity to the D2 receptor.
2) The 5HT2 receptor binding study was conducted with 3[H]-detanserin and the cortical tissues. The Bmax and Kb were 57.34 fmole/mg protein. 0.08 nM, respectively. None of them showed affinity to the 5HT2 receptor.
3) From the results. We could suppose that each component of Whangryeonhaedoktang has no effect on D2 and 5HT2 receptors. But the possibility that their phamacological effect might be mediated through their interrelationship or their effects on
the
other receptors such as GABA should not be ruled out.
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